The cytoskeleton is the structural framework that supports cellular form and function. More than a static structure, the cytoskeleton is a true nanomachine used for mechanical tasks across the biological scale, from organelles to organisms. The protozoan Giardia lamblia, is an intriguing single-celled parasite that depends on its cytoskeleton to latch onto the host intestine and maintain parasitism. Either due to its ancient origins or the selective pressure of its life as a parasite, Giardia lacks many cytoskeletal proteins once thought to be conserved in all eukaryotes.