The Hehnly Lab investigates how cellular and intracellular mechanisms establish the Left-Right Organizer (LRO) in vertebrates, a critical structure for body axis formation. Using zebrafish as a model, the lab explores how motile and non-motile cilia within the LRO generate fluid flow or potentially sense it, impacting asymmetric organ development. Open questions include how cells differentiate to form motile versus non-motile cilia and the roles these cilia play in development.

A plant’s roots serve as a major line of defense against environmental stress to protect the plant as a whole. Roots of diverse plant species have found ways to deal with stress by devising responses, often within individual cell types, to resist drought, mineral deficiencies, pathogens and other insults that impair plant growth. I will present my lab’s research that uses systems, and developmental biology approaches to interrogate the transcriptional networks that function in response to many of these environmental stresses in tomato and sorghum.

Computational models are essential tools that can be used to simultaneously explain and guide biological intuition. My lab employs agent-based modeling, machine learning, and dynamical systems to explain biological observations and to uncover design principles that drive individual cellular decisions as well as cell population dynamics. We are interested in the inherent multiscale nature of biology, with a specific focus on system-level dynamics that emerge from interactions of simpler individual-level modules.