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Cell and Molecular Biology

Dynamic Regulation of cell adhesion and motility governs the formation of the embryonic axis in vertebrate embryos

How do vertebrate embryos develop to form the adult organism? Coordinated cell movements during gastrulation are key to laying down the early embryonic body plan. The cells migrate by two distinct mechanisms that I will describe. They can migrate on extracellular matrix or on their neighboring cells. In zebrafish embryos, endoderm cells migrate on the yolk extracellular matrix to form the organs of the gut.

Mechanistic insights into actin force generation during vesicle formation from cryo-electron tomography

Serwas D, Akamatsu M, Moayed A, Vegesna K, Vasan R, Hill JM, Schöneberg J, Davies KM, Rangamani P, Drubin DG.  2022.  Mechanistic insights into actin force generation during vesicle formation from cryo-electron tomography. Developmental Cell.

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