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Cell and Molecular Biology

Ca <sup>2+</sup> -Permeable AMPARs Mediate Glutamatergic Transmission and Excitotoxic Damage at the Hair Cell Ribbon Synapse

Sebe JY, Cho S, Sheets L, Rutherford MA, von Gersdorff H, Raible DW.  2017.  Ca 2+ -Permeable AMPARs Mediate Glutamatergic Transmission and Excitotoxic Damage at the Hair Cell Ribbon Synapse. The Journal of Neuroscience. 37(25):6162-6175.

Genetic and epigenetic control of meiotic recombination in plant genomes

Meiosis is a highly conserved eukaryotic cell division that produces gametes required for sexual reproduction. During meiosis, homologous chromosomes undergo recombination, which can result in reciprocal crossover and gene conversion. Meiosis and recombination have a profound effect on natural genetic variation and genome evolution, which in turn has strategic importance for crop breeding. I will present our work using genome-wide methods to map meiotic recombination, primarily in the model plant Arabidopsis thaliana.

Environmental control of somatosensory neuron development and function

My laboratory’s long-term goal is to understand how environmental signals shape somatosensory neuron (SSN) structure and function. SSNs shape our experience of the world, allowing for perception and discrimination of pain, touch, pressure, and movement, and are a focal point of a growing human health crisis. Nearly twenty million Americans suffer from peripheral neuropathies, and one in three individuals in the U.S. will suffer from chronic pain.

Overcoming Structure / Stability Trade-offs in Ecological Networks

Many biological phenomena arise from the scaling from individual interactions (e.g., between genes, proteins, metabolites, cells including neurons, organs, organisms, and species) to systems. Network approaches have transformed the study of such systems, given that the structure of networks is typically non-random and often strongly related to system-level functioning and response to perturbations. Still, many network structural features are associated with clear trade-offs.


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