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Cell and Molecular Biology

High numerical aperture cryogenic localization microscopy: a technique for increased precision of super-resolution reconstructions

The precision of localization-based super-resolution microscopy techniques fundamentally relies on the point-spread function of the optical system and the number of photons one can collect. Here, we report that by using a high-numerical aperture objective lens and a custom cryogenic stage, we are able to increase photon yield by 2-3 fold over room temperature, thereby achieving more precise super-resolution reconstructions of complex subcellular structures.

Rapamycin Does Not Impede Survival or Induction of Antibody Responses to Primary and Heterosubtypic Influenza Infections in Mice.

JS L, A P, AR H, A K, EN J, W C, F L, MZ L, S S, S G.  2016.  Rapamycin Does Not Impede Survival or Induction of Antibody Responses to Primary and Heterosubtypic Influenza Infections in Mice.. Viral Immunology. 29(8)

Prior infection with influenza virus but not vaccination leaves a long-term immunological imprint that intensifies the protective efficacy of antigenically drifted vaccine strains.

JH K, J L, AJ R, X L, N M, J J, S S.  2016.  Prior infection with influenza virus but not vaccination leaves a long-term immunological imprint that intensifies the protective efficacy of antigenically drifted vaccine strains.. Vaccine. 34(4)

Biphasic clearance of incompatible red blood cells through a novel mechanism requiring neither complement nor Fcγ receptors in a murine model.

JS L, EA H, S S, CM C, SL S, JC Z.  2012.  Biphasic clearance of incompatible red blood cells through a novel mechanism requiring neither complement nor Fcγ receptors in a murine model.. Transfusion. 52(12)

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