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Development

Mechanics of anteroposterior axis formation in vertebrates

Measuring cell-generated forces and tissue mechanical properties in vivo and in situ has proven very difficult. For this reason, our understanding of how feedback loops between biochemical signaling and mechanics contribute to robust multicellular morphogenesis is still poor. To address this limitation, I helped develop a technique based on ferrofluid droplets which allows to measure multiple mechanical parameters at time- and length-scales relevant for embryonic development.

There are always flowers for those who want to see them

The integration of developmental genetics and evolution is providing a powerful synthesis towards understanding the mechanisms underlying the generation of biodiversity. Functional studies across the phylogenetic landscape are facilitating a comparative, integrative view highlighting that genes are mostly repurposed into new roles. I will present micro- and macro-evolutionary approaches on the evolutionary consequences of the emergence of novel traits in three distinct plant systems: an angiosperm, a gymnosperm and a fern.

Juvenile hormone reveals mosaic developmental programs in the metamorphosing optic lobe of Drosophila melanogaster.

Riddiford LM, Truman JW, Nern A.  2018.  Juvenile hormone reveals mosaic developmental programs in the metamorphosing optic lobe of Drosophila melanogaster.. Biology Open . 7:bio034025.

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