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The human body contains ~ 3.72 x 1013 cells and 200 different cell types. Generating the right number and types of cells is vital for embryogenesis, morphogenesis and tissue homeostasis. Such cellular diversity can be generated and maintained through asymmetric cell division (ACD), an evolutionary conserved process. ACD can be manifested in sibling cell size differences, distinct biochemical and molecular identities, or differences in subsequent division patterns.