Behavior

Adult Neurogenesis Leads to the Functional Reconstruction of a Telencephalic Neural Circuit

Submitted by Eliot A.-Brenowitz on Mon, Apr 2, 2018

Cohen R.E. 2016. Adult Neurogenesis Leads to the Functional Reconstruction of a Telencephalic Neural Circuit.

Possible decision-making preadaptations in the molly Poecilia sphenops

Submitted by Joya-Mukerji on Wed, Mar 28, 2018

Gould J.L, Zabka TS, Malizia RW, Park A, Mukerji J. 1999. Possible decision-making preadaptations in the molly Poecilia sphenops. 2(2):-95.

Female preferences in a fish genus without female mate choice

Submitted by Joya-Mukerji on Wed, Mar 28, 2018

Gould JL, Elliott SL, Masters CM, Mukerji J. 1999. Female preferences in a fish genus without female mate choice. Current Biology. 9(9):-500.

Epigenetic regulation of centromeres in early development: Fluorescence based technologies for long term, high spatio- temporal resolution

Centromeres are fundamental to eukaryotic cell division, required for establishing kinetochores tofacilitate faithful microtubule based chromosome segregation. The histone-H3 variant CENtromere-Protein-A (CENP-A) is thought to provide centromere identity and as such must be retained through each cell cycle. DNA replication halves the number of CENP-A containing nucleosomes at centromeres and work in various model systems has shown that new molecules are incorporated outside of S-phaseby a unique mechanism.

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Synchronizing in Seattle: Entrainment of networked brain circadian clocks

Last year, we celebrated the Nobel Prize in Medicine or Physiology awarded for the discoveries of the molecular basis of daily rhythms in cells. These circadian (~24 h) rhythms are common across phyla and cell types. In vertebrates, the suprachiasmatic nucleus (SCN) synchronizes circadian rhythms in behavior and physiology to the external light cycle, but the mechanisms by which this occurs are unclear.

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Jeff Riffell on mosquitoes in UW Today

Read more about Jeff Riffell on mosquitoes in UW Today

Asymmetric stem cell division and germ cell immortality

Asymmetric cell division is a fundamental mechanism to diversify cell fates. Adult stem cells often divide asymmetrically to generate one stem cell and one differentiating cell to maintain tissue homeostasis. Non-random sister chromatid segregation has been proposed as a potential mechanism utilized by stem cells to protect the genome from mutations or to confer distinct epigenetic information to daughter cells. However, the underlying mechanisms or the biological significance of such a phenomenon has never been directly demonstrated.