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Computational Biology

A Thirsty future: will tropical forests survive with more droughts and fires?

Tropical woody plants store ∼230 petagrams of carbon in their above-ground living biomass. These stocks are currently growing in primary forests at rates that have decreased in recent decades. Droughts are an important mechanism in reducing forest carbon uptake and stocks by elevating tree mortality, increasing autotrophic respiration, and promoting wildfires. With continued climate change, the intensity and frequency of droughts will likely increase, with land-use change intensifying their effects.

Self-organization and load adaptation by mammalian endocytic actin networks

Force generation by actin assembly shapes cellular membranes. The mechanisms that govern the organization of cytoskeletal complexes to produce directional force in cells are not understood, particularly in the localized membrane deformations required for membrane trafficking. An experimentally constrained multiscale model shows that a minimal branched actin network is sufficient to internalize endocytic pits against membrane tension. Around 200 activated Arp2/3 complexes are required for robust internalization.


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