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Biomechanics

Understanding the temporal and spatial cellular dynamics of making a Left-Right Organizer

The Hehnly Lab investigates how cellular and intracellular mechanisms establish the Left-Right Organizer (LRO) in vertebrates, a critical structure for body axis formation. Using zebrafish as a model, the lab explores how motile and non-motile cilia within the LRO generate fluid flow or potentially sense it, impacting asymmetric organ development. Open questions include how cells differentiate to form motile versus non-motile cilia and the roles these cilia play in development.

Melinda Denton Endowed Lecture: "Environmental integration with cell type development"

A plant’s roots serve as a major line of defense against environmental stress to protect the plant as a whole. Roots of diverse plant species have found ways to deal with stress by devising responses, often within individual cell types, to resist drought, mineral deficiencies, pathogens and other insults that impair plant growth. I will present my lab’s research that uses systems, and developmental biology approaches to interrogate the transcriptional networks that function in response to many of these environmental stresses in tomato and sorghum.

Behavioral Ecophysics

Our Behavioral Ecophysics lab focuses on the study of organismal mechanisms (e.g., physiology, biomechanics) in light of biotic and abiotic interactions, with the goal of establishing explicit links between physical laws and rules of life, from individual to ecological scales. A central challenge of biological studies is to describe functional links between underlying architecture (e.g., genotype, phenotype) and emergent phenomena (e.g., performance, ecological patterns).

Adventures in cell herding: understanding and controlling collective cell migration

We are working to accomplish for cells something like what a shepherd and sheepdogs bring to flocks of sheep: control over large-scale collective cellular motion. As coordinated cellular motion is foundational to many forms of multicellular life, being able to ‘herd’ or program large-scale cell migration raises exciting possibilities for accelerated healing, tissue engineering, and novel biomaterials.

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