Avian eggs are remarkably varied in their color, pattern, shape, size and ultrastructure. What evolutionary forces have affected their appearance and form? Using a multidisciplinary approach, I will explore the phenotypic diversity of avian eggs from functional and mechanistic perspectives, focusing on cuckoo egg mimicry, speckled songbird eggs, shorebird egg camouflage and nano-scale shell structure.
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Genetics and Genomics
The mission of the Allen Institute for Cell Science is to understand and predict cellular behaviors. Our initial project takes an integrative approach, developing high replicates of dynamic, visual data on cell organization and activities using endogenous fluorescently tagged human induced pluripotent stem cells. We are quantifying the relative locations and dynamics of the major cellular structures and activities as the stem cells go through the cell cycle and differentiate into cardiomyocytes andrespond to environmental perturbations and drugs.
During animal development, homeostasis, and aging, anything that grows eventually decays or undergoes consumption, which is known as atrophy or wasting. Thus, like growth, wasting is a fundamental biological process. Importantly, wasting is also part of a complex systemic disorder associated with many diseases. Cachexia, the wasting syndrome commonly observed in advanced cancer patients, affects approximately eight million people worldwide. Due to the complexity of the disease, it is challenging to dissect the molecular mechanisms of cachexia.