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Genetics and Genomics

Asymmetric stem cell division and germ cell immortality

Asymmetric cell division is a fundamental mechanism to diversify cell fates. Adult stem cells often divide asymmetrically to generate one stem cell and one differentiating cell to maintain tissue homeostasis. Non-random sister chromatid segregation has been proposed as a potential mechanism utilized by stem cells to protect the genome from mutations or to confer distinct epigenetic information to daughter cells. However, the underlying mechanisms or the biological significance of such a phenomenon has never been directly demonstrated.

Insights into the Evolution and Function of Auxin Signaling F-Box Proteins in <i>Arabidopsis thaliana</i> Through Synthetic Analysis of Natural Variants

R. Wright C, Zahler ML, Gerben SR, Nemhauser JL.  2017.  Insights into the Evolution and Function of Auxin Signaling F-Box Proteins in Arabidopsis thaliana Through Synthetic Analysis of Natural Variants. Genetics. :genetics.300092.2017.

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