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Computational Biology

Timing of antimicrobial use influences the evolution of antimicrobial resistance during disease epidemics

Tanaka M.M, Althouse B.M, Bergstrom C.T.  2014.  Timing of antimicrobial use influences the evolution of antimicrobial resistance during disease epidemics. Evolution, Medicine, and Public Health. 2014(1):150-161.

Final Cut: Cortical Dynamics during Cytokinesis

During cytokinesis, a cortical contractile ring forms around the cell equator and constricts to partition the contents of the mother cell into the two daughter cells. Cytokinesis represents a paradigm for a temporally and spatially controlled cellular shape change that is achieved by regulation of the actomyosin cortex.  I will present two new studies related to the mechanism of cytokinesis conducted in the one-cell C. elegans embryo. To initiate cytokinesis, the anaphase spindle sends a stimulatory signal to the cell equator that promotes cortical contractility.

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