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Clemens-Cabernard

Clemens Cabernard
Professor
ccabern@uw.edu
LSB361 LSB
(206) 616-7368
Cabernard lab website
Accepting graduate students
Fields of interest
Cell and Molecular Biology, Development, Neurobiology

My lab is studying asymmetric cell division (ACD), a process that generates cellular diversity.

We are using Drosophila melanogaster neuroblasts, the neural stem cells in the fly as a model to study the molecular cell biology and mechanics of asymmetric stem cell division. Currently my lab is focusing on the following topics: (1) the molecular mechanisms underlying the establishment and maintenance of centrosome asymmetry and biased centrosome segregation. (2) Myosin dynamics and cleavage furrow positioning during asymmetric cell division. (3) Mechanical and biophysical mechanisms involved in ACD.

To investigate these topics, we are using a combination of classical genetics, live cell imaging, superresolution imaging, molecular genetics and biophysical measurements.

Find out more here: https://www.cabernardlab.org

Positions:

2016 -              Assistant Professor, Department of Biology, University of Washington

2011 – 2016:   Assistant Professor, SNSF, Biozentrum, University of Basel, Switzerland

 

Education:

2006 – 2011:   Postdoctoral fellow; Institute of Molecular Biology, University of Oregon, USA

2004:               PhD; Biozentrum, University of Basel, Switzerland

2000:               M.S; Biozentrum, University of Basel, Switzerland

1998:               B.A; University of Basel, Switzerland

Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells, Roubinet, Chantal, Tsankova Anna, Pham Tri Thanh, Monnard Arnaud, Caussinus Emmanuel, Affolter Markus, and Cabernard Clemens , Nature Communications, 2017/11/09, Volume 8, Issue 1, p.1383, (2017)
Cell Polarity Regulates Biased Myosin Activity and Dynamics during Asymmetric Cell Division via Drosophila Rho Kinase and Protein Kinase N, Tsankova, Anna, Pham Tri Thanh, Garcia David Salvador, Otte Fabian, and Cabernard Clemens , Developmental Cell, Volume 42, Issue 2, p. - 155.e5, (2017)
Sibling cell size matters, Cabernard, Clemens , eLife, jan, Volume 6, (2017)
Myosin efflux promotes cell elongation to coordinate chromosome segregation with cell cleavage, Montembault, Emilie, Claverie Marie-Charlotte, Bouit Lou, Landmann Cedric, Jenkins James, Tsankova Anna, Cabernard Clemens, and Royou Anne , Nature Communications, 2017/08/23, Volume 8, Issue 1, p.326, (2017)
The Microcephaly-Associated Protein Wdr62/CG7337 Is Required to Maintain Centrosome Asymmetry in Drosophila Neuroblasts., Ramdas Nair, Anjana, Singh Priyanka, Salvador Garcia David, Rodriguez-Crespo David, Egger Boris, and Cabernard Clemens , Cell reports, 2016 Jan 20, (2016)
Asymmetrically dividing Drosophila neuroblasts utilize two spatially and temporally independent cytokinesis pathways., Roth, Michaela, Roubinet Chantal, Iffländer Niklas, Ferrand Alexia, and Cabernard Clemens , Nature communications, 2015, Volume 6, p.6551, (2015)
The centriolar protein Bld10/Cep135 is required to establish centrosome asymmetry in Drosophila neuroblasts., Singh, Priyanka, Ramdas Nair Anjana, and Cabernard Clemens , Current biology : CB, 2014 Jul 7, Volume 24, Issue 13, p.1548-55, (2014)
Control of asymmetric cell division., Roubinet, Chantal, and Cabernard Clemens , Current opinion in cell biology, 2014 Dec, Volume 31, p.84-91, (2014)
Live imaging of neuroblast lineages within intact larval brains in Drosophila., Cabernard, Clemens, and Doe Chris Q. , Cold Spring Harbor protocols, 2013 Oct, Volume 2013, Issue 10, p.970-7, (2013)
Neurogenesis: premature mitotic entry lets cleavage planes take off!, Singh, Priyanka, and Cabernard Clemens , Current biology : CB, 2012 Jan 10, Volume 22, Issue 1, p.R25-8, (2012)
Cytokinesis in Drosophila melanogaster., Cabernard, Clemens , Cytoskeleton (Hoboken, N.J.), 2012 Oct, Volume 69, Issue 10, p.791-809, (2012)
Asymmetric cortical extension shifts cleavage furrow position in Drosophila neuroblasts., Connell, Marisa, Cabernard Clemens, Ricketson Derek, Doe Chris Q., and Prehoda Kenneth E. , Molecular biology of the cell, 2011 Nov, Volume 22, Issue 22, p.4220-6, (2011)
Cell division orientation in animals., Gillies, Taryn E., and Cabernard Clemens , Current biology : CB, 2011 Aug 9, Volume 21, Issue 15, p.R599-609, (2011)
A spindle-independent cleavage furrow positioning pathway., Cabernard, Clemens, Prehoda Kenneth E., and Doe Chris Q. , Nature, 2010 Sep 2, Volume 467, Issue 7311, p.91-4, (2010)