Unwrapping Glial Engineering in the Vertebrate Nervous System
The long-term goal of the Kucenas Lab is to fundamentally understand the cellular and molecular mechanisms that mediate neural-glial and glial-glial interactions during nervous system development and injury/regeneration. Using Danio rerio (zebrafish) as a model system, we combine genetic and pharmacological perturbation, single cell manipulation, laser ablation/axotomy, small molecule screening, and in vivo, time-lapse imaging to directly and continuously observe glial cell origins, behaviors, and interactions in an intact vertebrate.
