Submitted by Vladimir-Minin on
Title | rbrothers: R Package for Bayesian Multiple Change-Point Recombination Detection. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Irvahn J, Chattopadhyay S, Sokurenko EV, Minin VN |
Journal | Evolutionary bioinformatics online |
Volume | 9 |
Pagination | 235-8 |
Date Published | 2013 |
ISSN | 1176-9343 |
Abstract | <p>Phylogenetic recombination detection is a fundamental task in bioinformatics and evolutionary biology. Most of the computational tools developed to attack this important problem are not integrated into the growing suite of R packages for statistical analysis of molecular sequences. Here, we present an R package, rbrothers, that makes a Bayesian multiple change-point model, one of the most sophisticated model-based phylogenetic recombination tools, available to R users. Moreover, we equip the Bayesian change-point model with a set of pre- and post- processing routines that will broaden the application domain of this recombination detection framework. Specifically, we implement an algorithm that forms the set of input trees required by multiple change-point models. We also provide functionality for checking Markov chain Monte Carlo convergence and creating estimation result summaries and graphics. Using rbrothers, we perform a comparative analysis of two Salmonella enterica genes, fimA and fimH, that encode major and adhesive subunits of the type 1 fimbriae, respectively. We believe that rbrothers, available at R-Forge: http://evolmod.r-forge.r-project.org/, will allow researchers to incorporate recombination detection into phylogenetic workflows already implemented in R.</p> |
DOI | 10.4137/EBO.S11945 |
Alternate Journal | Evol. Bioinform. Online |