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Auxin-induced degradation dynamics set the pace for lateral root development.

TitleAuxin-induced degradation dynamics set the pace for lateral root development.
Publication TypeJournal Article
Year of Publication2015
AuthorsGuseman JM, Hellmuth A, Lanctot A, Feldman TP, Moss BL, Klavins E, CalderĂ³n Villalobos L IA, Nemhauser JL
JournalDevelopment (Cambridge, England)
Volume142
Issue5
Pagination905-9
Date Published2015 Mar 1
ISSN1477-9129
Keywordsarabidopsis, Arabidopsis Proteins, Saccharomyces cerevisiae, Gene Expression Regulation, Plant, Indoleacetic Acids, Plant Growth Regulators, Plant Roots
Abstract

<p>Auxin elicits diverse cell behaviors through a simple nuclear signaling pathway initiated by degradation of Aux/IAA co-repressors. Our previous work revealed that members of the large Arabidopsis Aux/IAA family exhibit a range of degradation rates in synthetic contexts. However, it remained an unresolved issue whether differences in Aux/IAA turnover rates played a significant role in plant responses to auxin. Here, we use the well-established model of lateral root development to directly test the hypothesis that the rate of auxin-induced Aux/IAA turnover sets the pace for auxin-regulated developmental events. We did this by generating transgenic plants expressing degradation rate variants of IAA14, a crucial determinant of lateral root initiation. Progression through the well-established stages of lateral root development was strongly correlated with the engineered rates of IAA14 turnover, leading to the conclusion that Aux/IAAs are auxin-initiated timers that synchronize developmental transitions.</p>

DOI10.1242/dev.117234
Alternate JournalDevelopment