|Title||RIG-I ligand enhances the immunogenicity of recombinant H7HA protein.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||W C*, JS L*, RP K, AJ R, JH K, AR H, S A, J S, P R, S G, IA Y, S S, co-1st-Authors *|
Avian H7N9 influenza virus infection with fatal outcomes continues to pose a pandemic threat and highly immunogenic vaccines are urgently needed. In this report we show that baculovirus-derived recombinant H7 hemagglutinin protein, when delivered with RIG-I ligand, induced enhanced antibody and T cell responses and conferred protection against lethal challenge with a homologous H7N9 virus. These findings indicate the potential utility of RIG-I ligands as vaccine adjuvants to increase the immunogenicity of recombinant H7 hemagglutinin.
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RIG-I ligand enhances the immunogenicity of recombinant H7HA protein.
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