You are here

Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation

TitleProteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation
Publication TypeJournal Article
Year of Publication2012
AuthorsMukerji J, Olivieri KC, Misra V, Agopian KA, Gabuzda D
Volume9
Issue1
Pagination33
Date Published2012/06/22
ISBN Number1742-4690
Abstract

HIV-1 Nef protein contributes to pathogenesis via multiple functions that include enhancement of viral replication and infectivity, alteration of intracellular trafficking, and modulation of cellular signaling pathways. Nef stimulates formation of tunneling nanotubes and virological synapses, and is transferred to bystander cells via these intercellular contacts and secreted microvesicles. Nef associates with and activates Pak2, a kinase that regulates T-cell signaling and actin cytoskeleton dynamics, but how Nef promotes nanotube formation is unknown.

URLhttps://doi.org/10.1186/1742-4690-9-33
Short TitleRetrovirology
Fields of interest: