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A highly immunogenic vaccine against A/H7N9 influenza virus.

TitleA highly immunogenic vaccine against A/H7N9 influenza virus.
Publication TypeJournal Article
Year of Publication2016
AuthorsW C*, JS L*, AO H, RP K, AR H, S A, JH K, AJ R, J S, JM K, S G, IA Y, SK M, S S, co-1st-Authors *
Start Page744

Since the first case of human infection in March 2013, continued reports of H7N9 cases highlight a potential pandemic threat. Highly immunogenic vaccines to this virus are urgently needed to protect vulnerable populations who lack protective immunity. In this study, an egg- and adjuvant-independent adenoviral vector-based, hemagglutinin H7 subtype influenza vaccine (HAd-H7HA) demonstrated enhanced cell-mediated immunity as well as serum antibody responses in a mouse model. Most importantly, this vaccine provided complete protection against homologous A/H7N9 viral challenge suggesting its potential utility as a pandemic vaccine.

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