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Linda-Wordeman

Linda Wordeman
Adjunct Professor
worde@uw.edu
G403 HSD
(206) 543-4135
Wordeman Lab
Not accepting graduate students
Fields of interest
Cell and Molecular Biology, Development

My lab studies microtubule dynamics, microtubule motors and chromosome segregation. We use human and mammalian cell lines to investigate the impact of microtubule motors and regulators of microtubule polymerization on the fidelity of cell division and chromosome instability. We use high resolution and super-resolution live cell imaging and total internal fluorescence (TIRF) microscopy in conjunction with fluorescent proteins, bio-sensors and gene-edited cell lines to investigate dynamic processes that govern chromosome segregation during mitosis.

Positions:

2015 - Adjunct Professor of Biology, University of Washington

2006 - Professor of Physiology & Biophysics, University of Washington

2000 - Associate Professor of Physiology & Biophysics, University of Washington

1994 - Assistant Professor of Physiology & Biophysics, University of Washington

Education:

1988-1994: Postdoctoral Fellow; University of California, San Francisco

1988: PhD; Zoology, University of California, Berkeley

1982: BA+Honors; Molecular Biology, University of California, Berkeley

Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells., Ertych, Norman, Stolz Ailine, Stenzinger Albrecht, Weichert Wilko, Kaulfuß Silke, Burfeind Peter, Aigner Achim, Wordeman Linda, and Bastians Holger , Nature cell biology, 2014 Aug, Volume 16, Issue 8, p.779-91, (2014)
MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment., Domnitz, Sarah B., Wagenbach Michael, Decarreau Justin, and Wordeman Linda , The Journal of cell biology, 2012 Apr 16, Volume 197, Issue 2, p.231-7, (2012)
Kif18A and chromokinesins confine centromere movements via microtubule growth suppression and spatial control of kinetochore tension., Stumpff, Jason, Wagenbach Michael, Franck Andrew, Asbury Charles L., and Wordeman Linda , Developmental cell, 2012 May 15, Volume 22, Issue 5, p.1017-29, (2012)
Long astral microtubules uncouple mitotic spindles from the cytokinetic furrow., Rankin, Kathleen E., and Wordeman Linda , The Journal of cell biology, 2010 Jul 12, Volume 190, Issue 1, p.35-43, (2010)
Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK., Cooper, Jeremy R., Wagenbach Michael, Asbury Charles L., and Wordeman Linda , Nature structural & molecular biology, 2010 Jan, Volume 17, Issue 1, p.77-82, (2010)
The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment., Stumpff, Jason, von Dassow George, Wagenbach Michael, Asbury Charles, and Wordeman Linda , Developmental cell, 2008 Feb, Volume 14, Issue 2, p.252-62, (2008)