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Mugdha-Sathe

Mugdha Sathe
Postdoctoral Scholar
Advisor:
mugdhas@uw.edu
512 LSB

Skin is one of the largest organs in our body and is subject to a variety of assaults, including infection and wounding. We have chosen the zebrafish scale explant system as a model skin tissue, since it retains several key features of animal skin, such as the co-existence of multiple cell types (e.g. epithelial, immune and mechanosensory cells). By using this ‘skin-on-glass’ system, we plan to investigate physicochemical aspects of wound healing. The overall goal of the proposed work is to develop a detailed mechanistic understanding of how different types of cells function together to drive wound healing in a complex tissue.

I have led a nomadic life so far. Growing up in India, I lived in six states and went to eight schools. Fortunately, I went to a single university (The Maharaja Rao University of Baroda) and I majored in Chemistry for my undergrad. Subsequently, I did my Masters in Biochemistry from the same university. I moved to Bangalore to join the National Centre for Biological Sciences (NCBS) for my PhD. I was co-advised by Prof. Satyajit (Jitu) Mayor and Prof. Mukund Thattai. For my graduate work I looked at how curvature sensing protein shape plasma membrane to make endocytic vesicles.
After my PhD, I moved to Seattle to join Theriot lab to study role of cell migration during wound healing.

Spoiled for Choice: Diverse Endocytic Pathways Function at the Cell Surface, Thottacherry, Joseph Jose, Sathe Mugdha, Prabhakara Chaitra, and Mayor Satyajit , Annual Review of Cell and Developmental Biology, Volume 35, p.55–84, (2019)
Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis, Sathe, Mugdha, Muthukrishnan Gayatri, Rae James, Disanza Andrea, Thattai Mukund, Scita Giorgio, Parton Robert G., and Mayor Satyajit , Nature Communications, dec, Volume 9, p.1835, (2018)
Exploiting cell-to-cell variability to detect cellular perturbations., Dey, Gautam, Gupta Gagan D., Ramalingam Balaji, Sathe Mugdha, Mayor Satyajit, and Thattai Mukund , PloS one, mar, Volume 9, p.e90540, (2014)