Charles D. Laird
Not accepting graduate students
Fields of interest
Our most recent work on epigenetics is facilitated by our development of three new methods that permit us to determine methylation patterns on both strands of individual DNA molecules (Laird et al., 2004).
Charles is a Professor of Biology at the University of Washington, Associate Director for Fragile X Research in the University's Center on Human Development and Disability, and a faculty member in the Department of Genome Sciences. He received his BS from the University of Oregon, and his PhD from Stanford University. Charles was a faculty member at the University of Texas at Austin prior to joining the University of Washington in 1971. He has also taught or carried out research at the Cold Spring Harbor Laboratories, the Zoology Institute of the University of Zurich, the Medical Research Council's Laboratory of Molecular Biology (Cambridge), the Department of Genetics at Cambridge University, the Zoology Department at University of Bergen, and the Fred Hutchinson Cancer Research Center.
Statistical inference of transmission fidelity of DNA methylation patterns over somatic cell divisions in mammals
Fu, Audrey Qiuyan, Genereux Diane P., Stoger Reinhard, Laird Charles D., and Stephens Matthew
, Ann. Appl. Stat., 2010, Volume 4, Issue 2, p.892, (2010)
Errors in the bisulfite conversion of DNA: modulating inappropriate- and failed-conversion frequencies
Genereux, D. P., Johnson W. C., Burden A. F., Stoger R., and Laird C. D.
, Nucleic Acids Research, 2008, Volume 36, Issue 22, (2008)
Two boys with fragile X syndrome and hepatic tumors
Wirojanan, J., Kraff J., Hawkins D. S., Laird C., Gane L. W., Angkustsiri K., Tassone F., and Hagerman R. J.
, Journal of Pediatric Hematology Oncology, 2008, Volume 30, Issue 3, p.239-241, (2008)
Encoding PCR products with batch-stamps and barcodes
McCloskey, M. L., Stoger R., Hansen R. S., and Laird C. D.
, Biochemical Genetics, 2007, Volume 45, Issue 11-12, p.761-767, (2007)
Hemimethylation and non-CpG methylation levels in a promoter region of human LINE-1 (L1) repeated elements
Burden, A. F., Manley N. C., Clark A. D., Gartler S. M., Laird C. D., and Hansen R. S.
, Journal of Biological Chemistry, 2005, Volume 280, Issue 15, p.14413-14419, (2005)
A population-epigenetic model to infer site-specific methylation rates from double-stranded DNA methylation patterns
Genereux, D. P., Miner B. E., Bergstrom C. T., and Laird C. D.
, Proceedings of the National Academy of Sciences of the United States of America, 2005, Volume 102, Issue 16, p.5802-5807, (2005)
Hairpin-bisulfite PCR: Assessing epigenetic methylation patterns on complementary strands of individual DNA molecules
Laird, C. D., Pleasant N. D., Clark A. D., Sneeden J. L., Hassan K. M. A., Manley N. C., Vary J. C., Morgan T., Hansen R. S., and Stoger R.
, Proceedings of the National Academy of Sciences of the United States of America, 2004, Volume 101, Issue 1, p.204-209, (2004)
Molecular barcodes detect redundancy and contamination in hairpin-bisulfite PCR
Miner, B. E., Stoger R. J., Burden A. F., Laird C. D., and Hansen R. S.
, Nucleic Acids Research, 2004, Volume 32, Issue 17, (2004)
Fragile sites in human chromosomes as regions of late-replicating DNA
Laird, Charles, Jaffe Elizabeth, Karpen Gary, Lamb Mary, and Nelson Rebecca
, Trends in Genetics, 1987, Volume 3, p.274-281, (1987)