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Pallidal neuron activity increases during sensory relay through thalamus in a songbird circuit essential for learning

TitlePallidal neuron activity increases during sensory relay through thalamus in a songbird circuit essential for learning
Publication TypeJournal Article
Year of Publication2007
AuthorsPerson AL, Perkel DJ
JournalJ Neurosci
Volume27
Issue32
Pagination8687-98
Date Published2007
ISBN Number1529-2401 (Electronic)0270-6474 (Linking)
KeywordsAcoustic Stimulation/methods, Action Potentials/physiology, Animals, Male, Globus Pallidus/*physiology, Learning/*physiology, Nerve Net/*physiology, Neurons, Afferent/*physiology, Songbirds/*physiology, Thalamus/*physiology
Abstract

Disinhibition of the thalamus remains the primary model of information transfer between the basal ganglia and the cortex. Yet in apparent conflict with this model, the globus pallidus, a GABAergic basal ganglia output structure, often exhibits marked increases in firing rate during movement. To investigate the translation of pallidal activity and its relay through the thalamus, we explored a basal ganglia-thalamic pathway essential for song learning in songbirds. We found that single units in the thalamic nucleus DLM of urethane-anesthetized adult male zebra finches responded selectively to playback of the bird's own song, like neurons in its upstream and downstream nuclei. Because the pallidal input to these neurons forms giant calyx-like synapses, we were able to record extracellular signals from these presynaptic terminals as well. Pallidal units were distinctly excited by song playback, suggesting an increase in GABAergic transmission in the thalamus during sensory processing. However, this overall increased firing rate was phasic, punctuated by rapid decelerations in firing rate. In several cases, we were able to record presynaptic and postsynaptic units simultaneously. Correlating the presynaptic and postsynaptic activity, we found that disinhibition of thalamus may entail pallidal firing rate decelerations rather than simple long pauses in spontaneous activity, as has long been assumed.

URLhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17687046