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Horacio-de la Iglesia

Horacio de la Iglesia
Professor
horaciod@uw.edu
259 LSB
(206) 616-4697
de la Iglesia lab
Not accepting graduate students
Fields of interest
Behavior, Neurobiology, Physiology

Our laboratory is interested in understanding how neural systems encode time and generate rhythmic physiological and behavioral outputs to adapt to the temporal structure of the environment. We use a comparative approach that capitalizes on animal models that range from the laboratory mouse to humans.

Virtually all living species have biological clocks that generate and control the daily cyclic variations in physiology and behavior, such us the sleep-wake cycle, rhythms in locomotor activity, core body temperature and hormonal secretion. In mammals, the master control of these so-called circadian rhythms is exerted by a biological clock located within the suprachiasmatic nucleus (SCN) of the brain. We use behavioral, physiological and molecular techniques in order to understand how the SCN, in concert with other circadian oscillators in the brain, generates and orchestrates this array of circadian rhythms. We also study human circadian rhthms through non-invasive methods to assess the effect of electric light and the urban environment on the timing and quality of sleep.

Horacio de la Iglesia finished his undergraduate studies in Biology at the University of Buenos Aires, Argentina. He got his PhD in Neuroscience and Behavior at the University of Massachusetts, Amherst, where working with Eric Bittman he studied the neuroanatomical interactions between the master circadian clock of mammals and the brain centers that control reproduction . He then continued his research on the neural control of circadian rhythms as a Post-doctoral Fellow and as an Instructor in the laboratory of William Schwartz at the University of Massachusetts Medical School. He was also an Instructor at Harvard University where he taught a course on Stem Cells. Dr. de la Iglesia joined the University of Washington Department of Biology in 2003.

Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism, Padilla, Stephanie L., Perez Jazmine G., Ben-Hamo Miriam, Johnson Christopher W., Sanchez Raymond E. A., Bussi Ivana L., Palmiter Richard D., and de la Iglesia Horacio O. , Current Biology, Jan-02-2019, (2019)
Sleepmore in Seattle: Later school start times are associated with more sleep and better performance in high school students, Dunster, Gideon P., de la Iglesia Luciano, Ben-Hamo Miriam, Nave Claire, Fleischer Jason G., Panda Satchidananda, and de la Iglesia Horacio O. , Science Advances, Dec-12-2018, Volume 4, Issue 12, p.eaau6200, (2018)
The Dorsal Medial Habenula Minimally Impacts Circadian Regulation of Locomotor Activity and Sleep, Hsu, Yun-Wei A., Gile Jennifer J., Perez Jazmine G., Morton Glenn, Ben-Hamo Miriam, Turner Eric E., and de la Iglesia Horacio O. , Journal of Biological Rhythms, Feb-10-2018, Volume 32261, Issue 54, p.444 - 455, (2017)
Guidelines for Genome-Scale Analysis of Biological Rhythms, Hughes, Michael E., Abruzzi Katherine C., Allada Ravi, Anafi Ron, Arpat Alaaddin Bulak, Asher Gad, Baldi Pierre, de Bekker Charissa, Bell-Pedersen Deborah, Blau Justin, et al. , Journal of Biological Rhythms, Feb-10-2018, Volume 32, Issue 5, p.380 - 393, (2017)
Influence of temperature on daily locomotor activity in the crab Uca pugilator, Mat, Audrey M., Dunster Gideon P., Sbragaglia Valerio, Aguzzi Jacopo, and de la Iglesia Horacio O. , PLOS ONE, Feb-04-2019, Volume 12, Issue 4, (2017)
Sleep research goes wild: new methods and approaches to investigate the ecology, evolution and functions of sleep, Rattenborg, Niels C., de la Iglesia Horacio O., Kempenaers Bart, Lesku John A., Meerlo Peter, and Scriba Madeleine F. , Philosophical Transactions of the Royal Society B: Biological Sciences, Jul-11-2018, Volume 372, Issue 1734, p.20160251, (2017)
Loss of β-adrenergic–stimulated phosphorylation of Ca V 1.2 channels on Ser1700 leads to heart failure, Yang, Linghai, Dai Dao-Fu, Yuan Can, Westenbroek Ruth E., Yu Haijie, West Nastassya, de la Iglesia Horacio O., and Catterall William A. , Proceedings of the National Academy of Sciences, Jun-12-2016, Volume 1138269269907, Issue 49110355, p.E7976 - E7985, (2016)
Ancestral Sleep, Veeman, Michael T., Axelrod Jeffrey D., Presland R. B., Barnes L., Combes S. A., Daniel T. L., Schubiger Margrit, Tomita Shuichiro, Sung Carl, Robinow Steven, et al. , Current Biology, 01/2016, Volume 26, Issue 7, p.R271 - R272, (2016)
Circadian Forced Desynchrony of the Master Clock Leads to Phenotypic Manifestation of Depression in Rats, Ben-Hamo, Miriam, Larson Tracy A., Duge Leanne S., Sikkema Carl, Wilkinson Charles W., de la Iglesia Horacio O., and ález ónica M. C. , eneuro, Jun-01-2016, Volume 3, Issue 6, p.ENEURO.0237-16.2016, (2016)
Fragmentation of Rapid Eye Movement and Nonrapid Eye Movement Sleep without Total Sleep Loss Impairs Hippocampus-Dependent Fear Memory Consolidation, Lee, Michael L., Katsuyama Ângela M., Duge Leanne S., Sriram Chaitra, Krushelnytskyy Mykhaylo, Kim Jeansok J., and de la Iglesia Horacio O. , Sleep, Jan-11-2016, Volume 39111193151410472191046521308981069210623416152312941715128114881052113459444722711111813121346, Issue 11, p.2021 - 2031, (2016)
Access to Electric Light Is Associated with Shorter Sleep Duration in a Traditionally Hunter-Gatherer Community, de la Iglesia, H. O., Fernandez-Duque E., Golombek D. A., Lanza N., Duffy J. F., Czeisler C. A., and Valeggia C. R. , Journal of Biological Rhythms, 08/2015, Volume 30, Issue 4, p.342 - 350, (2015)
Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome, Kalume, Franck, Oakley John C., Westenbroek Ruth E., Gile Jennifer, de la Iglesia Horacio O., Scheuer Todd, and Catterall William A. , Neurobiology of Disease, 05/2015, Volume 77, p.141 - 154, (2015)
Time-Specific Fear Acts as a Non-Photic Entraining Stimulus of Circadian Rhythms in Rats, Pellman, Blake A., Kim Earnest, Reilly Melissa, Kashima James, Motch Oleksiy, de la Iglesia Horacio O., and Kim Jeansok J. , Scientific Reports, 10/2015, Volume 5, p.14916, (2015)
Identification, Characterization, and Diel Pattern of Expression of Canonical Clock Genes in Nephrops norvegicus (Crustacea: Decapoda) Eyestalk, Sbragaglia, Valerio, Lamanna Francesco, M. Mat Audrey, Rotllant Guiomar, Joly Silvia, Ketmaier Valerio, de la Iglesia Horacio O., and Aguzzi Jacopo , PLOS ONE, 11/2015, Volume 10, Issue 11, p.e0141893, (2015)
Mechanisms of Circadian Systems in Animals and Their Clinical RelevanceIntroduction to Circadian Rhythms, Clocks, and Its Genes, de la Iglesia, Horacio O., Lee Michael L., and Aguilar-Roblero Raúl , Cham, p.1 - 12, (2014)
Circadian Mechanisms of Food Anticipatory Rhythms in Rats Fed Once or Twice Daily: Clock Gene and Endocrine Correlates, Patton, Danica F., Katsuyama Ângela M., Pavlovski Ilya, Michalik Mateusz, Patterson Zachary, Parfyonov Maksim, Smit Andrea N., Marchant Elliott G., Chung John, Abizaid Alfonso, et al. , PLoS ONE, 12/2014, Volume 9, Issue 12, p.e112451, (2014)
Role of the Dorsal Medial Habenula in the Regulation of Voluntary Activity, Motor Function, Hedonic State, and Primary Reinforcement, Hsu, Y. - W. A., Wang S. D., Wang S., Morton G., Zariwala H. A., de la Iglesia H. O., and Turner E. E. , Journal of Neuroscience, 08/2014, Volume 34, Issue 34, p.11366 - 11384, (2014)
Re-examining "Temporal Niche", Smarr, B. L., Schwartz M. D., Wotus C., and de la Iglesia H. O. , Integrative and Comparative Biology, 07/2013, Volume 53, Issue 1, p.165 - 174, (2013)
Forced Desynchrony Reveals Independent Contributions of Suprachiasmatic Oscillators to the Daily Plasma Corticosterone Rhythm in Male Rats, Wotus, Cheryl, Lilley Travis R., Neal Adam S., Suleiman Nicole L., Schmuck Stefanie C., Smarr Benjamin L., Fischer Brian J., and de la Iglesia Horacio O. , PLoS ONE, 7/2013, Volume 8, Issue 7, p.e68793, (2013)
Biological Clocks: Riding the Tides, de la Iglesia, Horacio O., and Johnson Carl Hirschie , Current Biology, 10/2013, Volume 23, Issue 20, p.R921 - R923, (2013)
Chronobiology by moonlight, Kronfeld-Schor, N., Dominoni D., de la Iglesia H., Levy O., Herzog E. D., Dayan T., and Helfrich-Forster C. , Proceedings of the Royal Society B: Biological Sciences, 08/2013, Volume 280, Issue 1765, (2013)
Loss of the SV2-like Protein SVOP Produces No Apparent Deficits in Laboratory Mice, Yao, Jia, de la Iglesia Horacio O., and Bajjalieh Sandra M. , PLoS ONE, 7/2013, Volume 8, Issue 7, p.e68215, (2013)
In search of a temporal niche, Hut, Roelof A., Kronfeld-Schor Noga, van der Vinne Vincent, and De la Iglesia Horacio , The Neurobiology of Circadian Timing, Volume 199, p.281 - 304, (2012)
Circadian Regulation of Cortisol Release in Behaviorally Split Golden Hamsters, Lilley, T. R., Wotus C., Taylor D., Lee J. M., and de la Iglesia H. O. , Endocrinology, 02/2012, Volume 153, Issue 2, p.732 - 738, (2012)
Autistic behavior in Scn1a+/- mice and rescue by enhanced GABAergic transmission, Han, S., Tai C., Westenbroek R. A., Yu F. H., Cheah C., Potter G. B., Rubenstein J. L., Scheuer T., de la Iglesia H. O., and Catterall W. A. , Nature, 2012, Volume 489:385-390, (2012)
cGMP-Phosphodiesterase Inhibition Enhances Photic Responses and Synchronization of the Biological Circadian Clock in Rodents, Plano, Santiago A., Agostino Patricia V., de la Iglesia Horacio O., and Golombek Diego A. , PLoS ONE, 5/2012, Volume 7, Issue 5, p.e37121, (2012)
The Dorsomedial Suprachiasmatic Nucleus Times Circadian Expression of Kiss1 and the Luteinizing Hormone Surge, Smarr, B. L., Morris E., and de la Iglesia H. O. , Endocrinology, 06/2012, Volume 153, Issue 6, p.2839 - 2850, (2012)
NaV1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms, Han, S., Yu F. H., Schwartz M. D., Linton J. D., Bosma M. M., Hurley J. B., Catterall W. A., and de la Iglesia H. O. , Proceedings of the National Academy of Sciences, 02/2012, Volume 109, Issue 6, p.E368 - E377, (2012)
Functional Conservation of Clock Output Signaling between Flies and Intertidal Crabs, Beckwith, E. J., Lelito K. R., Hsu Y. - W. A., Medina B. M., Shafer O., Ceriani M. F., and de la Iglesia H. O. , Journal of Biological Rhythms, 12/2011, Volume 26, Issue 6, p.518 - 529, (2011)
Distinct patterns of Period gene expression in the suprachiasmatic nucleus underlie circadian clock photoentrainment by advances or delays, Schwartz, W. J., Tavakoli-Nezhad M., Lambert C. M., Weaver D. R., and de la Iglesia H. O. , Proc Natl Acad Sci U S A, 2011, Volume 108, p.17219-17224, (2011)
Phase Misalignment between Suprachiasmatic Neuronal Oscillators Impairs Photic Behavioral Phase Shifts But Not Photic Induction of Gene Expression, Schwartz, M. D., Congdon S., and de la Iglesia H. O. , J Neurosci, 2010, Volume 30, Issue 39, p.13150-6, (2010)
Biological clocks and rhythms in intertidal crustaceans, de la Iglesia, H. O., and Hsu Y. W. , Front Biosci (Elite Ed), 2010, Volume 2, p.1394-404, (2010)
Circadian timing of REM sleep is coupled to an oscillator within the dorsomedial suprachiasmatic nucleus, Lee, M. L., Swanson B. E., and de la Iglesia H. O. , Curr Biol, 2009, Volume 19, Issue 10, p.848-52, (2009)