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Cell and Molecular Biology

Molecular evolution of Drosophila Cdc6, an essential DNA replication-licensing gene, suggests an adaptive choice of replication origins

Wiggins BL, Malik HS.  2007.  Molecular evolution of Drosophila Cdc6, an essential DNA replication-licensing gene, suggests an adaptive choice of replication origins. Fly. 1(3):-163.

Stressed! How plants cope through dynamic responses.

One of our greatest challenges in the next 50 years will be to realize a global society that is fully sustainable.  Water is the most limiting resource for plant growth and agriculture uses between 70-80% of the fresh water supply.  Despite its critical importance, key questions remain regarding how plants sense, transport and efficiently use water.  My research aims to understand plant-environment interactions using a holistic approach that emphasizes the importance of developmental pathways and molecular genetic me

High numerical aperture cryogenic localization microscopy: a technique for increased precision of super-resolution reconstructions

The precision of localization-based super-resolution microscopy techniques fundamentally relies on the point-spread function of the optical system and the number of photons one can collect. Here, we report that by using a high-numerical aperture objective lens and a custom cryogenic stage, we are able to increase photon yield by 2-3 fold over room temperature, thereby achieving more precise super-resolution reconstructions of complex subcellular structures.

Rapamycin Does Not Impede Survival or Induction of Antibody Responses to Primary and Heterosubtypic Influenza Infections in Mice.

JS L, A P, AR H, A K, EN J, W C, F L, MZ L, S S, S G.  2016.  Rapamycin Does Not Impede Survival or Induction of Antibody Responses to Primary and Heterosubtypic Influenza Infections in Mice.. Viral Immunology. 29(8)

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