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Cell and Molecular Biology
One of our greatest challenges in the next 50 years will be to realize a global society that is fully sustainable. Water is the most limiting resource for plant growth and agriculture uses between 70-80% of the fresh water supply. Despite its critical importance, key questions remain regarding how plants sense, transport and efficiently use water. My research aims to understand plant-environment interactions using a holistic approach that emphasizes the importance of developmental pathways and molecular genetic me
The precision of localization-based super-resolution microscopy techniques fundamentally relies on the point-spread function of the optical system and the number of photons one can collect. Here, we report that by using a high-numerical aperture objective lens and a custom cryogenic stage, we are able to increase photon yield by 2-3 fold over room temperature, thereby achieving more precise super-resolution reconstructions of complex subcellular structures.