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Cell and Molecular Biology
Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells
Submitted by David W. Raible on
Ca <sup>2+</sup> -Permeable AMPARs Mediate Glutamatergic Transmission and Excitotoxic Damage at the Hair Cell Ribbon Synapse
Submitted by David W. Raible on
Distinct progenitor populations mediate regeneration in the zebrafish lateral line
Submitted by David W. Raible on
Genetic and epigenetic control of meiotic recombination in plant genomes
Meiosis is a highly conserved eukaryotic cell division that produces gametes required for sexual reproduction. During meiosis, homologous chromosomes undergo recombination, which can result in reciprocal crossover and gene conversion. Meiosis and recombination have a profound effect on natural genetic variation and genome evolution, which in turn has strategic importance for crop breeding. I will present our work using genome-wide methods to map meiotic recombination, primarily in the model plant Arabidopsis thaliana.
Environmental control of somatosensory neuron development and function
My laboratory’s long-term goal is to understand how environmental signals shape somatosensory neuron (SSN) structure and function. SSNs shape our experience of the world, allowing for perception and discrimination of pain, touch, pressure, and movement, and are a focal point of a growing human health crisis. Nearly twenty million Americans suffer from peripheral neuropathies, and one in three individuals in the U.S. will suffer from chronic pain.
Overcoming Structure / Stability Trade-offs in Ecological Networks
Many biological phenomena arise from the scaling from individual interactions (e.g., between genes, proteins, metabolites, cells including neurons, organs, organisms, and species) to systems. Network approaches have transformed the study of such systems, given that the structure of networks is typically non-random and often strongly related to system-level functioning and response to perturbations. Still, many network structural features are associated with clear trade-offs.
Learning to swim, again: Axon regeneration in fish
Submitted by Jeff Rasmussen on
Vertebrate epidermal cells are broad-specificity phagocytes that clear sensory axon debris
Submitted by Jeff Rasmussen on
Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization.
Submitted by Jeff Rasmussen on
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