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Cell and Molecular Biology

Unwrapping Glial Engineering in the Vertebrate Nervous System

The long-term goal of the Kucenas Lab is to fundamentally understand the cellular and molecular mechanisms that mediate neural-glial and glial-glial interactions during nervous system development and injury/regeneration. Using Danio rerio (zebrafish) as a model system, we combine genetic and pharmacological perturbation, single cell manipulation, laser ablation/axotomy, small molecule screening, and in vivo, time-lapse imaging to directly and continuously observe glial cell origins, behaviors, and interactions in an intact vertebrate.

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