Bio:
Phyllis M. Wise became Provost and Vice President for Academic Affairs at the University of Washington on August 2005. As of September 2007, her new title is Provost and Executive Vice President. She previously served as dean of the College of Biological Sciences at the University of California at Davis from 2002 to 2005. Prior to that, she was professor and chair of the Department of Physiology at the University of Kentucky from 1993 to 2002. Wise was a faculty member at the University of Maryland, Baltimore from 1976 to 1993, promoting through the ranks to full professor of physiology in 1987. She holds a bachelor's degree (1967) from Swarthmore College in biology and a doctorate (1972) degree in zoology from the University of Michigan. She was awarded an honorary doctor of science degree from Swarthmore College (2008). She was elected a member of the Institute of Medicine (2008) and a Fellow of the AAAS (2008).
As the UW's chief academic and budgetary officer, she provides leadership in educational and curriculum development, formulation and allocation of budget and space, long-range strategic planning, and management of the University’s research programs. She serves as deputy to the President and provides advice and assistance to him and to the Deans and the faculty in these matters. Dr. Wise serves or has served on a number of scientific advisory committees, including the NIH Biochemical Endocrinology Study Section, which she chaired for 3 years, the NIH Advisory Committee on Research in Women's Health, advisory boards for the Oregon and Wisconsin Regional Primate Center, the scientific advisory council for the Society of Women's Health Research, the advisory board of the University of Michigan Nathan Shock Center for Biological Aging, the Kronos Research Foundation Board of Directors and the Buck Institute Board of Directors.
Wise was featured in Parade Magazine cover story on "The Quiet Heroes" engaged in lifesaving research and has received many awards, including the Award for Excellence in Science from the Federation of American Societies for Experimental Biology in 2002, and the Women in Endocrinology Mentor Award in 2003. She was also selected by the Endocrine Society in 2004 as the recipient of the Roy O. Greep Award for outstanding contributions to research in endocrinology. These awards recognize outstanding contributions to original research.
Wise has been continuously funded by the NIH since 1980, and has received two MERIT (Method to Extend Research in Time) awards from the National Institutes of Health, from 1986 to 1996 and again from 2001 to 2010. MERIT awards provide NIH grant recipients with funding for innovative research over an extended period of time.
Research Interests:
Mechanisms regulating neural plasticity during aging, with particular emphasis on their impact on the female reproductive system
Neuroprotective actions of estrogen after injury and during aging
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Selected Publications:
Dubal DB, Wise PM 2001 Neuroprotective effects of estradiol in middle-aged female rats. Endocrinology 142:43-48
Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM 2001 Estrogen receptor alpha and not beta, is a critical link in estradiol-mediated protection against brain injury. Proceedings of the National Academy of Science, USA 98:1952-1957
Smith MJ, Wise PM 2001 Neurotensin gene expression increases during proestrus in the rostral preoptic nucleus: potential for direct communication with GnRH neurons. Endocrinology 142:3006-3013
Le W-W, Wise PM, Hoffman GE 2001 Parallel declines in fos activation of the medial anteroventral periventricular (AVPv) nucleus and LHRH neurons in middle-aged rats. Endocrinology 142:4976-4982
Wilson ME, Liu Y, Wise PM 2002 Estradiol enhances Akt activation in cortical explant cultures following neuronal injury. Molecular Brain Research 102:88-94
Cashion AB, Smith MJ, Wise PM 2003 The morphometry of astrocytes in the rostral preoptic area (rPOA) exhibits a diurnal rhythm on proestrus: relationship to the LH surge and effects of age. Endocrinology 144:274-280
Krajnak K, Rosewell KL, Duncan M, Wise PM 2003 Aging, estradiol and time of day differentially affect serotonin transporter binding in the central nervous system of female rats. Brain Research 990:87-94
Rau SW, Dubal DB, Böttner M, Wise PM 2003 Estradiol differentially regulates c-Fos after focal cerebral ischemia. Journal of Neuroscience 23:10487-10494
Rau SW, Dubal DB, Böttner M, Gerhold LM, Guttmann RP, Wise PM 2003 Estradiol attenuates markers of programmed cell death after focal cerebral ischemia. Journal of Neuroscience 23:11420-11426
Turgeon JL, McDonnell DP, Martin KA, Wise PM 2004 Hormone therapy: physiological complexity belies their therapeutic simplicity. Science 304:1269-1273
Gerhold LM, Rosewell KL, Wise PM 2005 Suppression of vasoactive intestinal polypeptide in the suprachiasmatic nucleus leads to aging-like changes in cAMP rhythms and activation of gonadotropin releasing hormone neurons. Journal of Neuroscience 25:62-67
Gerhold LM and Wise PM 2006 Vasoactive intestinal polypeptide regulates dynamic changes in astrocyte morphometry: Impact on gonadotropin releasing hormone neurons. Endocrinology 147:2197-2202
Dubal DB, Rau SW, Shughrue PJ, Zhu H, Yu J, Cashion AB, Suzuki S, Gerhold LM, Böttner M, Dubal SB, Merchenthaler I, Kindy M, Wise PM 2006 Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a novel role for ER alpha; in estradiol-mediated protection against programmed cell death. Endocrinology 147:3076-3084
Suzuki S, Gerhold LM, Böttner M, Rau SW, DelaCruz, C, Yang E, Zhu H, Yu J, Cashion AB, Kindy MS, Merchenthaler I, Gage FH, Wise PM 2007 Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors alpha and beta. Journal of Comparative Neurology 500:1064-1075
Suzuki S, Brown CM, Dela Cruz, C, Yang E, Bridwell D, Wise PM 2007 Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and anti-inflammatory actions. Proceedings of the National Academy of Science 104:6013-6018.
Jelks KAB, Wylie RL, Floyd CL, McAllister AK, Wise PM 2007 Estradiol targets synaptic proteins to induce glutamatergic synapse formation in cultured hippocampal neurons: critical role of estrogen receptor-alpha. Journal of Neuroscience 27:6903-6913
Brown CM, Dela Cruz CD, Yang E, Wise PM 2008 Inducible nitric oxide synthase and estradiol exhibit complementary neuroprotective roles after ischemic brain injury. Experimental Neurology 210:782-787
Teaching Interests:
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