Bio:
Dr. Bosma attended McGill University in Montreal as an undergraduate in Neurobiology and Comparative Physiology, and then obtained her Ph.D. in the Physiology Department at UCLA. After post-doctoral work on modulation of ion channels in the laboratory of Dr. Bertil Hille (Physiology and Biophysics, UW) and mutagenesis of ion channels in the laboratory of Dr. Bruce Tempel (Pharmacology, UW), she joined the faculty of the Zoology (now Biology) Department here at UW.
Research Interests:
 Our lab focuses on the early development of motor neurons found in the segmented hindbrain of both mouse and zebrafish; these neurons innervate the muscles of the face, and correct functioning of these neurons is required for proper swallowing, chewing and speech, and the coordination of these tasks with respiration. Using intracellular calcium imaging and patch clamp techniques, immunocytochemistry, and tissue culture techniques, we are exploring the functional development of ion channels in motor neurons identified using retrograde dextran labeling. We find that over very short developmental periods (12-24 hours), the expression of voltage-gated ion channels, gap junction channels and synaptic proteins change dramatically. We are interested in how these changes modify the development of peripheral synapses in the facial region.
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Selected Publications:
Hunt PN, Gust J, McCabe AK and Bosma MM. Primary role of the serotonergic midline system in synchronized spontaneous activity during development of the embryonic mouse hindbrain. J. Neurobiol. 2006b (in press).
Hunt PN, McCabe AK, Gust J and Bosma MM. Spatial restriction of spontaneous activity towards the rostral primary initiating zone during development of the embryonic mouse hindbrain. J. Neurobiol. 2006a (in press).
Moody WJ and Bosma MM. Ion channel development, spontaneous activity, and activity-dependent development in nerve and muscle cells. (Review). Physiol. Rev. 85:883- 941. 2005.
Hunt PN, McCabe AK and Bosma MM. Midline serotonergic neurons drive widespread synchronized activity in embryonic mouse hindbrain. J. Physiol. 566:807-819. 2005.
Corlew R, Bosma MM, Moody WJ. Spontaneous, synchronous electrical activity in neonatal mouse cortical neurones. J. Physiol. 560: 377-390. 2004.
Gust J, Wright JJ, Pratt EB and Bosma MM. Development of synchronized activity of cranial motor neurons in the segmented embryonic mouse hindbrain. J. Physiol. 550:123-133. 2003.
Street VA, Bosma MM, Demas V, Robinson LC, Regan M, Agnew WS and Tempel BL. The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse. J. Neurosci. 17:635-645. 1997.
Hille B, Tse A, Tse FW and Bosma MM. Signaling mechanisms during the GnRH response of pituitary gonadotropes. Recent Prog. Horm. Res. 50:75-95. 1995.
Bosma MM. Ion channel properties and episodic activity in isolated immortalized gonadotropin-releasing (GnRH) neurons. J. Memb. Biol. 136:85-96. 1993.
Bosma MM, Allen ML, Martin TM and Tempel BL. PKA-dependent regulation of mKv1.1, a mouse Shaker-like potassium channel gene, when stably expressed in CHO cells. J. Neurosci. 13:5242-5250. 1993.
Bosma MM and Hille B. Electrophysiological properties of a cell line of the gonadotrope lineage. Endocrinology 130:3411-3420. 1992.
Teaching Interests:
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